周非凡（博士），教授、博士生导师，获全国百篇优秀博士学位论文，国家海外高层次人才青年项目，海南省第十届青年科技奖，当选SPIE FELLOW。2010获华南师范大学光学专业博士学位；2010-2013 华南师范大学 历任助理研究员、副研究员；2014-2018 美国俄克拉荷马中央大学 历任研究助理、研究助理教授、研究副教授；2018-2020深圳大学 特聘教授；2020 冰球突破 教授。

  主要研究方向： 

1) 肿瘤光学精准诊疗技术研发；

2) 神经免疫可视化及调控研究。

  学术论文： 

在Nature Communication、Brain Behavior and Immunity、Nano Letter、 Clinical Cancer Research等国际知名学术期刊发表SCI论文50余篇，被引5000余次；入选2022、2023年度全球2 %高被引科学家。

文章详见：http://scholar.google.com/citations?user=aIzZwnwAAAAJ&hl=en

  代表性论文： 

1. Wang M, Yan C, Li X, Yang T, Wu S, Liu Q, Luo Q*, Zhou F*. Non-invasive modulation of meningeal lymphatics ameliorates ageing and Alzheimer’s disease-associated pathology and cognition in mice. Nature Communications (2024) 15:1453. (综合性期刊1区)

2. Rao J, Sun W, Wang X, Li J, Zhang Z, Zhou F*. A novel role for astrocytic fragmented mitochondria in regulating morphine addiction, Brain Behav. Immun. 2023, 113, 328-339. (神经科学1区)

3. Wang M#, Yan D#, Wang M, Wu Q, Song R, Huang Y, Rao J, Wang D*, Zhou F*, Tang BZ*. A versatile 980 nm absorbing aggregation-induced emission luminogen for NIR-II imaging-guided synergistic photo-immunotherapy against advanced pancreatic cancer, Adv. Funct. Mater.2022, 2205371. (工程技术1区)

4. Wang M, Li Y, Wang M, Liu K, Hoover AR, Li M, Towner RA, Mukherjee P, Zhou F*, Qu J*, Chen WR*. Synergistic Interventional Photothermal Therapy and Immunotherapy Using an Iron Oxide Nanoplatform for the Treatment of Pancreatic Cancer, Acta Biomaterialia, 2022, 138(15): 453-462.(工程技术1区) 入选高被引论文

5. Wang M, Rao J, Wang M, Li X*, Liu K, Naylor M F, Nordquist R E, Chen W R*, Zhou F*. Cancer photo-immunotherapy: from bench to bedside. Theranostics 2021, 11 (5), 2218-2231. (医学1区) 入选高被引论文

  主持科研项目： 

1. 科技创新2030-“脑科学与类脑智能”重大项目青年项目，针对脑膜淋巴管微环境实时检测和调控的活体多模态光学关键技术与系统研究，2022.08-2026.07，500万，在研；

2. 国自然面上项目，基于肿瘤微环境活体影像评价光免疫协同治疗及其机制研究2022.01-2025.12，55万，在研；

3. 海南省科技人才创新项目，改善老年神经认知功能的无损光学调控及监控技术研发，2024.01-2025.12，100万，在研；

4. 万宁市中信局横向项目，槟榔神经影响比对研究，2022.05-2025.04，300万，在研；

5. 海南省重点研发项目，影像引导的前列腺癌激光免疫精准治疗技术研发，2021.09-2023.09，40万，结题；

6. 国自然海外青年英才基金，2019.01-2022.12，200万，结题；

7. 广东省科技厅重点研发项目，基于光声成像的鼻咽癌激光免疫精准诊疗技术研究，2019.01-2022.12，300万，结题。

  获奖与荣誉称号：  

2013  FEBS J 学术期刊高引用奖;

2013  教育部科学技术奖二等奖 (骨干);

2014  全国百篇优秀博士学位论文；

2017  国家海外高层次人才青年项目入选者；

2022  海南省优秀研究生导师；

2023  海南省青年科技奖；

2024 SPIE Fellow

  学术兼职：  

国际光学工程学会（SPIE）Photonics West “Biophotonics and Immune Responses”会议的委员会共主席（Program Committee Chair），中国生物医学工程学会生物医学光子学分会委员，中国抗癌协会肿瘤精准治疗分会委员，海南省生物医学工程学会理事长。

  招生需求： 

招收神经生物学、肿瘤学、免疫学、光学、生物医学工程及相关专业的硕士生、博士生、博士后和预聘教师。

邮箱：zhouff@m2methods.net

Feifan Zhou, PhD.
Professor, PhD supervisor
School of Biomedical Engineering
Hainan University, Haikou, China
Email: zhouff@m2methods.net

Professor Feifan Zhou was the gainer of  Excellent Doctoral Thesis Award of China and National Overseas High-level Talents Youth Program. She have published more than 50 peer-reviewed papers with more than 3000 citations. She also received several research grants, delivered several invited talks in international conferences, and served as members in many academic organizations.

Research Interests
Optical technology in tumor theranostics and neuroimmune regulation
Nanomaterials based theranostics for cancer and neurodegenerative diseases
Synergized phototherapy and immunotherapy for metastatic cancer

Education
09/2000-07/2004  Bioscience B.S. Henan University, China
09/2005-06/2010  Optics     Ph.D.  South China Normal University, China

Positions
07/2010-12/2011     Assistant Professor of Research, South China Normal University
01/2012-12/2013     Associate Professor of Research, South China Normal University
01/2014-09/2015     Research Associate, University of Central Oklahoma
10/2015-05/2017     Assistant Professor of Research, University of Central Oklahoma
06/2017-06/2018     Associate Professor of Research, University of Central Oklahoma
07/2018-07/2020     Professor, Shenzhen University
08/2020- present     Professor, Hainan University

Awards
2017   High-level Youth Talents Program
2013   Excellent Doctoral Thesis Award of China
2012   Excellent Doctoral Thesis Award of Guangdong, China
2012   Ministry of Education Science and Technology Progress Award, China
2011   Academic Journal High Citation Award in 2011, FEBS J

Patents
A device and a method for imaging-guided photothermal laser therapy for cancer treatment, 2018 US9,987,089 B2, US Patent.
A hand-held intervention device and using method of hand-held intervention device, 201910369172.9, China Patent

Relevant Peer-Reviewed Publications
▶  Feifan Zhou#*, Meng Wang#, Teng Luo, Junle Qu*, Wei R. Chen*. Photo-activated chemo-immunotherapy for metastatic cancer using a synergistic graphene nanosystem. Biomaterials 2021; 265, 120421.
▶  Feifan Zhou#, Jingxuan Yang#, Yuqing Zhang, Mingyang Liu, Mark L Lang, Min Li*, Wei R Chen*, Local phototherapy synergizes with immunoadjuvant for treatment of pancreatic cancer through induced immunogenic tumor vaccine. Clinical Cancer Research 2018;24(21):5335-5346.  
▶  Mark F. Naylor, Feifan Zhou*, Brian V. Geister, Robert E. Nordquist, Wei R. Chen, Treatment of advanced melanoma with laser immunotherapy and ipilimumab. J Biophotonics 2017, 10(5), 618-622.
▶  Feifan Zhou#, Xiaosong Li#, Mark F. Naylor, Tomas Hode, Robert E. Nordquist, Luciano Alleruzzo, Joseph Raker, Samuel S.K. Lam, Nan Du, Lei Shi, Xiuli Wang, Wei R. Chen*. InCVAX - A novel strategy for treatment of late-stage, metastatic cancers through photoimmunotherapy induced tumor-specific immunity. Cancer Lett. 2015, 395, 169-177.
▶  Feifan Zhou, Shengnan Wu, Sheng Song, Wei R. Chen, Daniel E. Resasco, Da Xing*, Antitumor immunologically modified carbon nanotubes for photothermal therapy. Biomaterials 2012, 33, 3235-3242.
▶  Sheng Song, Feifan Zhou*, Wei R. Chen, Low-level laser therapy regulates microglial function through Src-mediated signaling pathways: implications for neurodegenerative diseases, J Neuroinflam 9, 219, 2012.
▶  Feifan Zhou#, Shengnan Wu#, Yi Yuan, Wei R. Chen, Da Xing*, Mitochondria targeting photoacoustic therapy using single-walled carbon nanotubes. Small 2012, 8, 1543–1550.
▶  Feifan Zhou#, Shengnan Wu#, Baoyan Wu, Wei R. Chen, Da Xing*, Mitochondria-targeting single-walled carbon nanotubes for cancer photothermal therapy, Small 2011, 7, 2727–2735.
▶  Feifan Zhou, Da Xing*, Baoyan Wu, Shengnan Wu, Zhongmin Ou, Wei R. Chen, New insights of transmembranal mechanism and subcellular localization of non covalently modified single-walled carbon nanotubes, Nano Lett. 2010, 10, 1677-1681.
▶  Feifan Zhou, Da Xing, ZhongminOu, Baoyan Wu, Daniel E. Resasco, Wei R. Chen, Cancer photothermal therapy in the near-infrared region by using single-walled carbon nanotubes, J. Biomed. Opt. 14(2), 021009, 2009.

Research Support
▶   Key R&D Project of Guangdong Provincial, Photoacoustic guided photo-immunotherapy for nasopharyngeal carcinoma, 2019.01-2021.12, 3 million yuan.
▶   National Natural Science Foundation of China (Youth Talents Program) , Basic research on the application of photoimmunotherapy, 2020.01-2022.12, 2 million yuan.
▶   National Natural Science Foundation of China, Basic research on mitochondria targeting carbon nanotubes mediated cancer laser therapy, 2012.01-2014.12, 220 thousands yuan.

Academic Service
▶   Program committee member, Biophotonics and Immune Responses Branch, Photonics West of Society of Photo-Optical Instrumentation Engineers (SPIE)
▶   Committee  member, Biomedical Photonics Branch, Chinese Society of Biomedical Engineering
▶   Youth committee  member, Photodynamic Therapy Branch, Chinese Anti-Cancer Association

Current Opening
Opening for Master students/PhD students/Post-doctoral Fellows/Pre-employed teachers in biology, medicine, optics, biomedical engineering and other related areas.