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23 2023.02

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    郭哲杉

郭哲杉(博士)。2019年博士毕业于浙江大学生物医学工程专业;2019-2022年在明尼苏达大学神经调控中心进行博士后研究;2022年4月就职于应脉冰球突破科技(上海)有限公司,任神经调控部高级科学家;2022年12月入职冰球突破。

  研究方向:

利用非人灵长类及大鼠疾病模型(帕金森病,癫痫,阿尔茨海默症等),通过在体电生理、影像学、计算机建模等手段,研究上述疾病的神经机制,并开发新型神经调控方法。研究领域涉及神经调控、脑机接口、脑电信号分析与处理等。

  学术论文:
1.  Guo Z, Feng Z*, Wang Y & Wei X. Simulation study of intermittent axonal block and desynchronization effect induced by high-frequency stimulation of electrical pulses[J]. Frontiers in Neuroscience, 2018, 12:858.

2.  Guo Z, Feng Z*, Yu Y, et al. Sinusoidal stimulation trains suppress epileptiform spikes induced by 4-AP in the rat hippocampal CA1 region in-vivo[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5817.

3.  Zheng L, Feng Z, Guo Z, Huang L. Simulation Study of Intermittent Responses of Neuronal Populations to Axonal High-Frequency Stimulation[C]. Conf Proc IEEE Eng Med Biol Soc, 2019: 3001-3004.

4.  Feng Z*, Guo Z, Wang Z. Advances in Understanding The Mechanisms of Deep Brain Stimulation[J]. Progress in Biochemistry and Biophysics, 2018, 45(12): 1197-1203.

5.  Cai Z, Feng Z*, Guo Z, Zhou W, Wang Z & Wei X. Novel stimulation paradigms with temporally-varying parameters to reduce synchronous activity at the onset of high frequency stimulation in rat hippocampus[J]. Frontiers in Neuroscience, 2017, 11:563.

6.  Feng Z*, Wang Z, Guo Z, Zhou W, Cai Z & Durand DM. High frequency stimulation of afferent fibers generates asynchronous firing in the downstream neurons in hippocampus through partial block of axonal conduction[J]. Brain Research, 2017, 1661:67.

7.  Yu Y, Feng Z*, Cao J, Guo Z, Wang Z, Hu N & Wei X. Modulation of local field potentials by high-frequency stimulation of afferent axons in the hippocampal CA1 region[J]. Journal of Integrative Neuroscience, 2016, 15(01):1-17.

8.  Wang Z, Feng Z*, Yu Y, Zhu Y & Guo Z. Detection of single unit spikes during orthodromic-high frequency stimulation in rat hippocampus[C]. Conf Proc IEEE Eng Med Biol Soc, 2016, 2016:5813.

9.  Feng Z*, Yu Y, Guo Z, Cao J & Durand DM. High frequency stimulation extends the refractory period and generates axonal block in the rat hippocampus[J]. Brain stimulation, 2014, 7(5): 680-689.

  主持和参与的部分科研项目:
1.  美国国立卫生研究院项目:“Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey”(4R37NS077657-10),2012-2025,67万美元(参与2019.5-2022.4)
2.  美国国立卫生研究院项目:“Basal Ganglia Cortical Coupling and Connectivity Changes in PD and DBS”( 5R01NS037019-23),1999-2023,220万美元(参与2019.5-2022.4)
3.  国家自然科学基金面上项目:大脑深部电刺激的神经网络作用机制研究(30970753),2010-2012,30万人民币,参与

  授权专利:

多功能神经电刺激系统控制软件 V1.0. 2015SR110707, 2015. (第二发明人)

联系方式: guozheshan@m2methods.net